6 CALL: 858.536.8044 • WEB: geneseesci.com • EMAIL: [email protected] Biosimilars Recombinant Proteins Lysates Biosimilars are monoclonal antibodies similar to regulatory-approved therapeutic antibodies. They are expressed recombinantly with the same sequence as the reference product but for research use only. Researchers can utilize these biologics as benchmarks in their studies in their studies, helping them to expedite the translation of laboratory findings into clinical practice. Laboratory-produced, purified proteins serve as critical tools for countless research endeavors. ProSci recombinant proteins can be used for various research areas, including cell growth and differentiation, cell signaling, and disease onset and progression. ProSci antibodies provide researchers with a variety of ready-to- use tissue lysates for proteomics research applications, including immunoblot analysis, immunoprecipitation, enzymatic activity analysis, and tissue-specific expression profiling. Select Citations: 1. PNAS (2011). 108: 17468-17473. (RHGAL-3) 2. J. Virol., (2011). 85: 2325-2332. (GrB) 3. J. Bacteriol. (2009). 191: 693-700. (RPlECHKD), (RPLED) SDS-Page analyses of recombinants ATG5 (Cat #: 95-121), DR6 (Cat #: 95-119), and EndoG (Cat #: 95-103) on Coomassie Blue-stained gradient gels, respectively) ELISA of Pembrolizumab (Cat #: 10-615) binding with PD-1 ELISA of Bevacizumab (Cat #: 10-068) binding with VEGF165 Select Citations: 1. J Biol Chem (2005). 280: 19543-19550. (Normal breast tissue lysates) 2. Hum Mol Genet (2008). 17: 859-871. (Human normal adult cerebral cortex tissue lysate) (Human fetal frontal lobe membrane protein lysate) 3. J Pharmacol Exp Ther (2010). 335: 533-545. (Human heart lysate) Cat # Description Immunogen 10-615 Pembrolizumab (PDCD1/PD1/CD279) Research Grade Biosimilar Humanized / PDCD1/ PD1/CD279 10-314 Solanezumab (APP Abeta,soluble monomer) - Research Grade Biosimilar Humanized / APP Abeta, Soluble Monomer 10-068 Bevacizumab (VEGFA) - Research Grade Biosimilar Humanized / VEGFA 10-841 Timigutuzumab (ERBB2/EGFR2/CD340) Research Grade Biosimilar Humanized / ERBB2/ EGFR2/CD340 Species Bovine Guinea Pig Human Monkey Mouse Plant Porcine Rabbit Rat Tissues Brain Heart Colon Lung Kidney Pancreas Application Key: E=ELISA, F=Flow Cytometry, IF=Immunofluorescence, ICC=Immunocytochemistry, IHC=Immunohistochemistry, IHC-P=Immunohistochemistry-Paraffin, WB=Western Blot Reactivity Key: H=Human, M=Mouse, R=Rat Scan here for more species and tissues: Cat # Description Application 95-121 ATG5 Recombinant Protein E,WB 95-119 DR6 Cytoplasmic Domain Recombinant Protein E, WB
